Proximagen Neuroscience plc
(the "Company")

SCHEDULE 11
NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS

1) Name of company


Proximagen Neuroscience plc


2) Name of director


Michael Ashton


3) Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18 or in respect of a non-beneficial
interest


As named in 2 above


4) Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them (if notified)


M Ashton Pension Scheme


5) Please state whether notification relates to a person(s) connected with the
Director named in 2 above and identify the connected person(s)


n/a


6) Please state the nature of the transaction. For PEP transactions please
indicate whether general/single co PEP and if discretionary/non discretionary


Share purchase


7) Number of shares/amount of stock acquired


2,000


8) Percentage of issued class


0.01%


9) Number of shares/amount of stock disposed


n/a


10) Percentage of issued class


n/a


11) Class of security


Ordinary 1p shares


12) Price per share


£1.18p


13) Date of transaction


27 December 2007


14) Date company informed


28 Dec 2007


15) Total holding following this notification


22,384


16) Total percentage holding of issued class following this notification


0.11%


17) Name of contact and telephone number for queries


James Hunter 020 7848 6011


18) Name and signature of authorised company official responsible for making
this notification


James Hunter

Date of Notification


31 December 2007